El cilio primario y su relación con el cáncer / Primary cilio and its relationship with cancer

Jennifer Whitley Tucker, Stephanie Browne, MSc. Zulema Ramírez Carmenate, Dra. Lucía González Núñez

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Resumen

El cilio primario es un organelo inmóvil localizado en casi todas las células del organismo humano. Es una prolongación filiforme de membrana citoplasmática, formado por un núcleo de nueve dobletes de microtúbulos periféricos, que capta señales mecánicas y químicas para formar una respuesta celular, la que está regulada de una manera coordinada con el ciclo celular, lo que indica su papel en la progresión tumoral. Su participación en la vía de señalización Hedgehog puede promover la proliferación celular y la sobre expresión de la misma puede causar cáncer. Dada la importancia del tema se realizó una revisión de 22 referencias bibliográficas con la finalidad de explicar la relación entre el cilio primario y el desarrollo de algunas variedades de cáncer a través de su estructura-función, destacando la vía de señalización Hedgehog.

Abstract
The primary cilium is an organelle in mobile localized in almost every cells of the human being. It is a vilifying prolongation of the cytoplasmic membrane, forming by a nucleus of nine doublets of micro peripheral tubules, which capture mechanical and chemical signals to form a cellular response, which is regulated in a coordinated manner with the cell cycle, which indicates its role in the turmeric progression. Its participation in the Hedgehog signaling path can promote cell proliferation and the over expression of it can cause cancer. Given the importance of the subject, a review of 22 bibliographic references was carried out to explain the relation between the primary cylinder and the development of varieties of cancer through its structure-function highlighting the Hedgehog signaling path.

Palabras clave

cilio primario, vía Hedgehog, tumorogénesis, meduloblastoma, carcinoma de células basales

Referencias

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